Age-dependency of thrombin generation

Age-dependency of thrombin generation.

Editorial Focus: Age-dependency of thrombin generation

Thromb Haemost 2006; 95: 756–7 The paper “Age dependency measured by calibrated automated thrombinography (CAT)” by Haidl et al. (1) is one in a series of investigations from the Graz group that significantly contributes to the understanding of paediatric haemostasis. More or less as a by-product of these studies they now found that adults of over 35 years of age have a significantly higher thr...

Assessment of Thrombin Generation

Thrombin plays a central role in haemostasis through both procoagulant and anticoagulant functions. Although measurement of thrombin generation in the laboratory has been possible for many years, recent advances in understanding a wider scope of physiological roles of thrombin as well as improvements in technology have resulted in methods that are less technically demanding and more reproducibl...

"Normal" thrombin generation.

We have investigated the influence of alterations in plasma coagulation factor levels between 50% and 150% of their mean values for prothrombin, factor X, factor XI, factor IX, factor VII, factor VIII, factor V, protein C, protein S, antithrombin III (AT-III), and tissue factor pathway inhibitor (TFPI) as well as combinations of extremes, eg, 50% anticoagulants and 150% procoagulants or 50% pro...

Platelets and thrombin generation.

This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin. Studies have demonstrated that on activation, the amount of one specific lipid, phos...